Publications

Group Publications

Manganese-Catalyzed Stereospecific Hydroxymethylation of Alkyl Tosylates
Hannah Shenouda, Erik J. Alexanian
Org. Lett. 2019, Accepted.

Identifying Amidyl Radicals for Intermolecular C-H Functionalizations
Special issue on C-H Bond Functionalization
Matthew M. Tierney, Stefano Crespi, Davide Ravelli, Erik J. Alexanian
J. Org. Chem. 2019, 84, 12983-12991.

C-H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C-H Bond
Carla M. Morton, Qilei Zhu, Hunter Ripberger, Ludovic Troian-Gautier, Zi S. D. Toa, Robert R. Knowles, Erik J. Alexanian
J. Am. Chem. Soc. 2019, 141, 13253-13260.

Chemo- and Regioselective Functionalization of Isotactic Polypropylene: A Mechanistic and Structure-Property Study
Jill B. Williamson, Christina G. Na, Robert R. Johnson III, William F. M. Daniel, Erik J. Alexanian, Frank A. Leibfarth
J. Am. Chem. Soc. 2019, 141, 12815-12823.

Nickel-Catalyzed, Ring-Forming Aromatic C-H Alkylations with Unactivated Alkyl Halides
Special issue in honor of Prof. John Hartwig's 2018 Tetrahedron Prize
Quentin D. Tercenio, Erik J. Alexanian
Tetrahedron 2019, 75, 4143-4149.

Cobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates: Stereospecific Synthesis of Amides
Brendon T. Sargent, Erik J. Alexanian
Angew. Chem. Int. Ed. 2019, 58, 9533-9536.

Transition-Metal (Pd, Ni, Mn)-Catalyzed C-C Bond Constructions Involving Unactivated Alkyl Halides and Fundamental Synthetic Building Blocks
Megan R. Kwiatkowski, Erik J. Alexanian
Acc. Chem. Res. 2019, 52, 1134-1144.

Nickel-Catalyzed Mizoroki-Heck-Type Reactions of Unactivated Alkyl Bromides
Megan R. Kwiatkowski, Erik J. Alexanian
Angew. Chem. Int. Ed. 2018, 57, 16857-16860.

A General Approach to Site-Specific, Intramolecular C-H Functionalization Using Dithiocarbamates
Christina G. Na, Erik J. Alexanian
Angew. Chem. Int. Ed. 2018, 57, 13106-13109.

Reagent-Dictated Site Selectivity in Intermolecular Aliphatic C-H Functionalizations Using Nitrogen-Centered Radicals
Anthony M. Carestia, Davide Ravelli, Erik J. Alexanian
Chem. Sci. 2018, 9, 5360-5365.

Regioselective C-H Xanthylation as a Platform for Polyolefin Functionalization
Jill B. Williamson, William L. Czaplyski, Erik J. Alexanian, Frank A. Leibfarth
Angew. Chem. Int. Ed. 2018, 57, 6261-6265.

A General Strategy for Aliphatic C-H Functionalization Enabled by Organic Photoredox Catalysis
Kaila A. Margrey, William L. Czaplyski, David A. Nicewicz, Erik J. Alexanian
J. Am. Chem. Soc. 2018, 140, 4213-4217.

Cobalt-Catalyzed Carbonylative Cross-Coupling of Alkyl Tosylates and Dienes: Stereospecific Synthesis of Dienones at Low Pressure
Brendon T. Sargent, Erik J. Alexanian
J. Am. Chem. Soc. 2017, 139, 12438-12440.

Palladium-Catalyzed Carbocyclizations of Unactivated Alkyl Bromides with Alkenes Involving Auto-tandem Catalysis
Alexander R. O. Venning, Megan R. Kwiatkowski, Joan E. Roque Pena, Brendan C. Lainhart, Akil A. Guruparan, Erik J. Alexanian
J. Am. Chem. Soc. 2017, 139, 11595-11600.

Cobalt-Catalyzed Silylcarbonylation of Unactivated Secondary Alkyl Tosylates at Low Pressure
Joan E. Roque Pena, Erik J. Alexanian
Org. Lett. 2017, 19, 4413-4415.

A General Approach to Quaternary Center Construction from Couplings of Unactivated Alkenes and Acyl Xanthates
Ernest N. Jenkins, William L. Czaplyski, Erik J. Alexanian
Org. Lett. 2017, 19, 2350-2353.

C-H Xanthylation: A Synthetic Platform for Alkane Functionalization
William L. Czaplyski, Christina G. Na, Erik J. Alexanian
J. Am. Chem. Soc. 2016, 138, 13854-13857.

Manganese-Catalyzed Carboacylations of Alkenes with Alkyl Iodides
Caitlin M. McMahon, Matthew S. Renn, Erik J. Alexanian
Org. Lett. 2016, 18, 4148-4150.

Palladium-Catalyzed Alkoxycarbonylation of Unactivated Secondary Alkyl Bromides at Low Pressure
Brendon T. Sargent, Erik J. Alexanian
J. Am. Chem. Soc. 2016, 138, 7520-7523.

Site-Selective Aliphatic C­H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide
Ryan Quinn, Zef Könst, Sharon Michalak, Yvonne Schmidt, Anne Szklarski, Alex Flores, Sangkil Nam, David Horne, Christopher Vanderwal, Erik Alexanian
J. Am. Chem. Soc. 2016, 138, 696-702.

Palladium-Catalyzed, Ring-Forming Aromatic C–H Alkylations with Unactivated Alkyl Halides
Alexander R.O. Venning , Patrick T. Bohan , Erik J. Alexanian
J. Am. Chem. Soc. 2015, 137, 3731–3734.

Stereoselective Nickel-Catalyzed [2+2] Cycloadditions of Ene-Allenes
Njamkou N. Noucti, Erik J. Alexanian
Angew. Chem. Int. Ed. 2015, 54, 5447-5450.

Enantioselective Synthesis of cis-Fused Cyclooctanoids via Rhodium(I)-Catalyzed [4+2+2] Cycloadditions
Brendan C. Lainhart, Erik J. Alexanian
Org. Lett. 2015, 17, 1284–1287.

Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light
Valerie A. Schmidt, Ryan K. Quinn, Andrew T. Brusoe, Erik J. Alexanian
J. Am. Chem. Soc. 2014, 136, 14389-14392.

Alkene Hydrofunctionalization Using Hydroxamic Acids: A Radical Mediated Approach to Alkene Hydration
Benjamin C. Giglio, Erik J. Alexanian
Org. Lett. 2014, 16, 4304-4307.

Palladium-Catalyzed Heck-Type Cross-Couplings of Unactivated Alkyl Iodides
Caitlin M. McMahon, Erik J. Alexanian
Angew. Chem. Int. Ed. 2014, 53, 5974-5977.

Radical Carbooxygenations of Alkenes Using Hydroxamic Acids
Ryan K. Quinn, Valerie A. Schmidt, Erik J. Alexanian
Chem. Sci. 2013, 4, 4030-4034.

Stereoselective Nickel-Catalyzed [2+2+2] Cycloadditions and Alkenylative Cyclizations of Ene-Allenes and Alkenes
Njamkou N. Noucti, Erik J. Alexanian
Angew. Chem. Int. Ed. 2013, 52, 8424-8427.

Enantioselective Intermolecular [2+2+2] Cycloadditions of Ene-Allenes with Allenoates
Andrew T. Brusoe, Rahul V. Edwankar, Erik J. Alexanian
Org. Lett. 2012, 14, 6096-6099.

Metal-Free, Aerobic Ketooxygenation of Alkenes Using Hydroxamic Acids
Valerie A. Schmidt, Erik J. Alexanian
Chem. Sci. 2012, 3, 1672-1674.

Palladium-Catalyzed Heck-Type Reactions of Alkyl Iodides
Kayla S. Bloome, Rebecca L. McMahen, Erik J. Alexanian
J. Am. Chem. Soc. 2011, 133, 20146-20148.

Metal-Free, Aerobic Dioxygenation of Alkenes Using Simple Hydroxamic Acid Derivatives
Benjamin C. Giglio, Valerie A. Schmidt, Erik J. Alexanian
J. Am. Chem. Soc. 2011, 133, 13320-13322.

Metal-Free Oxyaminations of Alkenes Using Hydroxamic Acids
Valerie A. Schmidt, Erik J. Alexanian
J. Am. Chem. Soc. 2011, 133, 11402-11405.

Rhodium(I)-Catalyzed Ene-Allene-Allene [2+2+2] Cycloadditions: Stereoselective Synthesis of Complex trans-Fused Carbocycles
Andrew T. Brusoe, Erik J. Alexanian
Angew. Chem. Int. Ed. 2011, 123, 6726-6730.

Palladium-Catalyzed Carbonylative Heck-Type Reactions of Alkyl Iodides
Kayla S. Bloome, Erik J. Alexanian
J. Am. Chem. Soc. 2010, 132, 12823-12825.

Metal-Free, Aerobic Dioxygenation of Alkenes Using Hydroxamic Acids
Valerie A. Schmidt, Erik J. Alexanian
Angew. Chem. Int. Ed. 2010, 49, 4491-4494.

Alexanian Publications (Graduate and Post-Doc)

Alexanian, E. J.; Hartwig, J. F. “Mechanistic Study of β-Hydrogen Elimination from Organoplatinum(II) Enolate Complexes”. J. Am. Chem. Soc. 2008, 130, 15627-15635.

Alexanian, E. J.; Lee, C.; Sorensen, E. J. “Palladium Catalyzed Ring-Forming Aminoacetoxylation of Alkenes”. J. Am. Chem. Soc. 2005, 127, 7680-7681.

Alexanian, E.; Lee, C. “Selective Oxidative Functionalization of sp2 and sp3 C-H Bonds”. Chemtracts 2005, 18, 38-43.

Anderson, E. A.; Alexanian, E. J.; Sorensen, E.J. "Synthesis of the Furanosteroidal Antibiotic Viridin". Angew. Chem. Int. Ed. 2004, 43, 1998-2001.

Weatherhead, G. S.; Ford, G. J.; Alexanian, E. J.; Schrock, R. R.; Hoveyda, A. H. "Tandem Catalytic Ring-Opening Metathesis/Ring-Closing Metathesis". J. Am. Chem. Soc. 2000, 122, 1828-1829.